Key Risk Factors for Colorectal Cancer

What Are the Risk Factors for Colorectal Cancer?





A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. For example, exposing skin to strong sunlight is a risk factor for skin cancer. Smoking is a risk factor for cancers of the lungs, larynx (voice box), mouth, throat, esophagus, kidneys, bladder, colon, and several other organs.



But risk factors don't tell us everything. Having a risk factor, or even several risk factors, does not mean that you will get the disease. And some people who get the disease may not have any known risk factors. Even if a person with colorectal cancer has a risk factor, it is often very hard to know how much that risk factor may have contributed to the cancer.



Researchers have found several risk factors that may increase a person's chance of developing colorectal polyps or colorectal cancer.

Risk factors you cannot change



Age

Younger adults can develop colorectal cancer, but the chances increase markedly after age 50. More than 9 out of 10 people diagnosed with colorectal cancer are older than 50.

Personal history of colorectal polyps or colorectal cancer



If you have a history of adenomatous polyps (adenomas), you are at increased risk of developing colorectal cancer. This is especially true if the polyps are large or if there are many of them.

If you have had colorectal cancer, even though it has been completely removed, you are more likely to develop new cancers in other areas of the colon and rectum. The chances of this happening are greater if you had your first colorectal cancer when you were younger.



Personal history of inflammatory bowel disease

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a condition in which the colon is inflamed over a long period of time. People who have had IBD for many years often develop dysplasia. Dysplasia is a term used to describe cells in the lining of the colon or rectum that look abnormal (but not like true cancer cells) when viewed under a microscope. These cells can change into cancer over time.



If you have IBD, your risk of developing colorectal cancer is increased, and you may need to be screened for colorectal cancer starting at an earlier age and on a more frequent basis (see the section, "Can colorectal cancer be found early?").



Inflammatory bowel disease is different from irritable bowel syndrome (IBS), which does not carry an increased risk for colorectal cancer.



Family history of colorectal cancer

Most colorectal cancers occur in people without a family history of colorectal cancer. Still, as many as 1 in 5 people who develop colorectal cancer have other family members who have been affected by this disease.



People with a history of colorectal cancer or adenomatous polyps in one or more first-degree relatives (parents, siblings, or children) are at increased risk. The risk is about doubled in those with a single affected first-degree relative. It is even higher if the first-degree relative is diagnosed at a young age, or if more than one first-degree relative is affected.



The reasons for the increased risk are not clear in all cases. Cancers can "run in the family" because of inherited genes, shared environmental factors, or some combination of these.



If you have a family history of adenomatous polyps or colorectal cancer, you should talk with your doctor about the possible need to begin screening before age 50. If you have had adenomatous polyps or colorectal cancer, it's important to tell your close relatives so that they can pass along that information to their doctors and start screening at the right age.



Inherited syndromes

About 5% to 10% of people who develop colorectal cancer have inherited gene changes that cause the disease. The 2 most common inherited syndromes linked with colorectal cancers are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC).



Familial adenomatous polyposis (FAP): FAP is caused by changes (mutations) in the APC gene that a person inherits from his or her parents. About 1% of all colorectal cancers are due to FAP.



People with this disease typically develop hundreds or thousands of polyps in their colon and rectum, usually in their teens or early adulthood. Cancer usually develops in 1 or more of these polyps as early as age 20. By age 40, almost all people with this disorder will have developed cancer if preventive surgery (removing the colon) is not done.



FAP is sometimes associated with Gardner syndrome, a condition that also involves benign (non-cancerous) tumors of the skin, soft connective tissue, and bones.



Hereditary non-polyposis colon cancer (HNPCC): HNPCC, also known as Lynch syndrome, accounts for about 3% to 5% of all colorectal cancers. HNPCC can be caused by inherited changes in a number of different genes that normally help repair DNA damage. (See the section, "Do we know what causes colorectal cancer?" for more details.)



This syndrome also develops when people are relatively young. People with HNPCC have polyps, but they only have a few, not hundreds as in FAP. The lifetime risk of colorectal cancer in people with this condition may be as high as 80%.



Women with this condition also have a very high risk of developing cancer of the endometrium (lining of the uterus). Other cancers linked with HNPCC include cancer of the ovary, stomach, small bowel, pancreas, kidney, brain, ureters (tubes that carry urine from the kidneys to the bladder), and bile duct.

For more information on HNPCC, see the sections, "Do we know what causes colorectal cancer?" and "Can colorectal cancer be prevented?"



Turcot syndrome: This is a rare inherited condition in which people are at increased risk of adenomatous polyps and colorectal cancer, as well as brain tumors. There are actually 2 types of



Turcot syndrome:

One can be caused by gene changes similar to those seen in FAP, in which cases the brain tumors are medulloblastomas.



The other can also be caused by gene changes similar to those seen in HNPCC, in which cases the brain tumors are glioblastomas.



Peutz-Jeghers syndrome: People with this rare inherited condition tend to have freckles around the mouth (and sometimes on the hands and feet) and large polyps in their digestive tracts. They are at greatly increased risk for colorectal cancer, as well as several other cancers, which usually appear at a younger than normal age.



Identifying families with these inherited syndromes is important because it allows doctors to recommend specific steps, such as screening and other preventive measures, at an early age.

Several types of cancer can be linked with these syndromes, so it's important to check your family medical history for polyps or any type of cancer. If you have had adenomatous polyps or cancer, it's important to tell your close relatives. People with a family history of colorectal polyps or cancer should consider genetic counseling to review their family medical tree and determine whether genetic testing may be right for them. If needed, this can help them decide about getting screened and treated at an early age. More information on genetic counseling and testing can be found in the section, "Can colorectal cancer be prevented?"



Racial and ethnic background

African Americans have the highest colorectal cancer incidence and mortality rates of all racial groups in the United States. The reasons for this are not yet understood.



Jews of Eastern European descent (Ashkenazi Jews) have one of the highest colorectal cancer risks of any ethnic group in the world. Several gene mutations leading to an increased risk of colorectal cancer have been found in this group. The most common of these DNA changes, called the I1307K APC mutation, is present in about 6% of American Jews.



Lifestyle-related factors

Several lifestyle-related factors have been linked to colorectal cancer. In fact, the links between diet, weight, and exercise and colorectal cancer risk are some of the strongest for any type of cancer.



Certain types of diets

A diet that is high in red meats (beef, lamb, or liver) and processed meats (hot dogs and some luncheon meats) can increase colorectal cancer risk. Cooking meats at very high temperatures (frying, broiling, or grilling) creates chemicals that might increase cancer risk, but it's not clear how much this might contribute to an increase in colorectal cancer risk. Diets high in vegetables and fruits have been linked with a decreased risk of colorectal cancer. It's not clear if other dietary components (fiber, certain types of fats, etc.) affect colorectal cancer risk.



Physical inactivity

If you are not physically active, you have a greater chance of developing colorectal cancer. Increasing activity may help reduce your risk.



Obesity

If you are very overweight, your risk of developing and dying from colorectal cancer is increased. Obesity raises the risk of colon cancer in both men and women, but the link seems to be stronger in men.



Smoking

Long-term smokers are more likely than non-smokers to develop and die from colorectal cancer. Smoking is a well-known cause of lung cancer, but some of the cancer-causing substances are swallowed and can cause digestive system cancers, like colorectal cancer.



Heavy alcohol use

Colorectal cancer has been linked to the heavy use of alcohol. At least some of this may be due to the fact that heavy alcohol users tend to have low levels of folic acid in the body. Still, alcohol use should be limited to no more than 2 drinks a day for men and 1 drink a day for women.



Type 2 diabetes

People with type 2 (usually non-insulin dependent) diabetes have an increased risk of developing colorectal cancer. Both type 2 diabetes and colorectal cancer share some of the same risk factors (such as excess weight). But even after taking these into account, people with type 2 diabetes still have an increased risk. They also tend to have a less favorable prognosis (outlook) after diagnosis.

Factors with uncertain, controversial, or unproven effects on colorectal cancer



Night shift work

Results of one study suggested working a night shift at least 3 nights a month for at least 15 years may increase the risk of colorectal cancer in women. The study authors suggested this might be due to changes in levels of melatonin (a hormone that responds to changes in light) in the body. More research is needed to confirm or refute this finding.



Previous treatment for certain cancers

Some studies have found that men who survive testicular cancer seem to have a higher rate of colorectal cancer and some other cancers. This might be due to the treatments they have received.

Several studies have suggested that men who received radiation therapy to treat prostate cancer may have a higher risk of rectal cancer because the rectum receives some radiation during treatment.



Most of these studies are based on men treated in the 1980s and 1990s, and the effect of more modern radiation methods on rectal cancer risk is not clear. There are many possible side effects of prostate cancer treatment that men should consider when making treatment decisions. Some doctors recommend that the risk of rectal cancer should be considered as one of those possible side effects.



The American Cancer Society and several other medical organizations recommend earlier screening for people with increased colorectal cancer risk. These recommendations differ from those for people at average risk. For more information, speak with your doctor and refer to the table in the "Can colorectal polyps and cancer be found early?" section of this document.



Last Medical Review: 02/16/2010

Last Revised: 02/16/2010



http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_colon_and_rectum_cancer.asp?rnav=cri